Endocrine Abstracts

Purpose: Subclinical hyperthyroidism is associated with cognitive impairment, but the mechanism has remained unclear. As subclinical hyperthyroidism is characterized by significantly decreased thyrotropin (TSH) levels, this study aimed to investigate whether TSH regulates cognitive function.Methods: The correlation between TSH and cognitive impairment was investigated in a cross-sectional population study including 382 participants wi...

Background: Pheochromocytomas and paragangliomas (PPGLs) are a group of rare neuroendocrine tumors. Dysglycemia has been observed in patients with PPGLs in some small case series. However, few large studies, and none in China, have described the outcomes of dysglycemia after resection, and the factors associated with the development and resolution of dysglycemia in patients with PPGLs.Methods: We retrospectively analyzed the clinical data of consecutive ...

Context: Gap junction intercellular communication (GJIC) and its constructed protein Connexin (Cx) participates in cell apoptosis and tumorigenesis. Our clinical studies demonstrated that a levonorgestrel (LNG)-releasing intrauterine system can reverse atypical endometrial hyperplasia.Objective: This study assesses whether LNG exerts anti-proliferation effects on human endometrial cells through changes in the GJIC function and Cx43 expression.<p clas...

Objective: Bisphenol A (BPA) exposure may promote obesity, but its effect on bone mineral density (BMD) has not been reported in humans. In the present study, we aimed to examine the complex interplay between BPA exposure, fat mass, fat-free mass, serum estradiol, leptin, osteocalcin levels and BMDs in a group of premenopausal women.Methods: A total of 246 Chinese premenopausal women aged 20 years and older with regular menstrual cycles were investigated...

Background: Cortisol is an essential steroid hormone released from the adrenal gland. Plasma cortisol levels follow a circadian rhythm under the control of the Hypothalamic–Pituitary–Adrenal axis, reaching peak levels in the morning. Cortisol has long been known to exert immunosuppressive effects and accordingly, glucocorticoids are central in treating inflammatory disease. Cortisol’s propensity to downregulate certain pro-inflammatory cytokines and upregulate o...

Background: Psoriasis is associated with a heightened prevalence of cardiovascular risk factors, including diabetes. However, it is not clear whether diabetes will cause differences on clinical outcomes of psoriatic patients who have already suffered from coronary artery disease.Methods: We conducted a retrospective cohort study of consecutive psoriatic patients with coronary artery disease between January 2017 and May 2022 in our hospital. The clinical ...

Background: Psoriasis is associated with a heightened prevalence of cardiovascular risk factors, including metabolic syndrome (MetS). As so far, it is not clear whether MetS will cause differences on clinical outcomes of psoriatic patients who have already suffered from coronary artery disease.Methods: We conducted a retrospective cohort study to determine the effects of MetS in psoriatic patients with coronary artery disease. Comparisons were made betwe...

Pharmacological treatment with synthetic glucocorticoids, which are widely prescribed for the treatment of numerous inflammatory and autoimmune diseases, can also affect the way the adrenal gland produces cortisol. Indeed, patients undergoing synthetic glucocorticoid treatment can develop adrenal insufficiency. This condition is characterised by reduced responsiveness of the adrenal to ACTH stimulation, and adrenal crisis/shock can occur in response to acute physiological stre...

Introduction: The visceral adipose tissue-derived serine protease inhibitor (vaspin), a novel adipocytokine, has been widely reported to be associated with obesity and insulin resistance. Obesity induced chronic inflammatory process plays a pivotal role in insulin resistance and is characterized by the activation of NF-κB pathway and its target genes. The present study aims to investigate the effects of vaspin on NF-κB pathway and its target genes in basal and TNF-&#...

Objective: The role of pancreatic insulin secretion in Chinese women with polycystic ovary syndrome (PCOS) is not clear. To evaluate insulin sensitivity (IS) and β-cell function in lean and obese women with PCOS, either separately or by using an disposition index (DI).Methods: Cross-sectional study involving 137 Chinese women with PCOS and 123 normal women were examined by anthropometry, lipid profile, sex hormone, high-sensitivity C-reactive protei...